Tray Dryers are a common method of dryer wetcakes and granulated drug products. This is especially true in the early product development phase.
Tray Dryers are a common method of dryer wetcakes and granulated drug products. This is especially true in the early product development phase. The issue of containment for this type of process equipment is unique in that open scooping of powder onto multiple trays that get slotted into the dryer one at a time prohibits a mass, single transfer as with charging a vessel through a nozzle.
There are many styles of Tray Dryers on the Market and installed that drive the Engineering Control here to a custom design. However, containment is accomplished with a standard set of interface and design techniques.
The various styles of dryers, interfaces, door types, volumes, ergonomics, and life cycle costs must all be taken into account in order to meet the need of containing the dryer. Included here is whether the dryer is portable or a fixed installation.
COMMON OPERATIONAL STEPS
The final design may vary from operation to operation but a typical installation includes adding a flange to the face of the dryer to the outside of the door. An enclosure made from the rugged ArmorFlex family of films is then attached to the flange and a supporting frame assembly. These features will allow for opening the door within an enclosed environment when loading and unloading the trays with the drug product.
The trays, drug product and associated process tools can either be preloaded into the enclosure or bagged into the isolated area via bag in/bag out (BIBO) canisters or larger drum ring attachment canisters. The steps outlined below represent a typical example of this type of process:
After processing is completed, spray mist the inside of the enclosure as part of the overall wash down. The flexible enclosure will then be removed from the dryer while wearing personal protective equipment (PPE) as part of the wash down process.