Products and Services
FBRM® C35
Source:
Mettler-Toledo International Inc.
Granule or particle size is a critical parameter in high shear wet granulation. Formulators and engineers can reduce development time up to 50% with FBRM® real-time granule size monitoring while targeting a particle size distribution providing uniform flow properties and tablet dissolution profiles.
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•Datasheet: FBRM® C35
•Brochure: Particle Characterization
•Brochure: Formulations
•Datasheet: FBRM® C35
•Brochure: Particle Characterization
•Brochure: Formulations
•Datasheet: FBRM® C35
•Brochure: Particle Characterization
•Brochure: Formulations
Granule or particle size is a critical parameter in high shear wet granulation. Formulators and engineers can reduce development time up to 50% with FBRM® real-time granule size monitoring while targeting a particle size distribution providing uniform flow properties and tablet dissolution profiles.
FBRM® in-line particle characterization can optimize and control batch-to-batch repeatability upon scale-up from the lab to the plant and ensure batches do not fail size specifications.
Target Granulation Batch Repeatability with FBRM® C35
- Avoid granulation upsets - Monitor changes in particle count and dimension during cohesive wet or dry particle processing, enabling Quality by Design (QbD) throughout granulation development, scale-up and manufacturing
- Control batch-to-batch repeatability - Troubleshoot unexpected process changes with FBRM® trends, and eliminate batch failures, improve yield, and troubleshoot scale-up or technology transfer
- Identify batch endpoint variation - Hit target endpoint particle distribution to ensure downstream particle flow, tableting and dissolution Ensure window cleanliness - A mechanical scraper keeps the FBRM® probe window clean allowing the system to track particle agglomeration, compaction and breakage even in the most cohesive particle conditions.
•Datasheet: FBRM® C35
•Brochure: Particle Characterization
•Brochure: Formulations
